02 November 2021: Articles
Glucocorticoids Induce Partial Remission of Focal Segmental Glomerulosclerosis but Not Interstitial Nephritis in COVID-19 Acute Kidney Injury in an APOL1 Low-Risk Genotype White Patient
Challenging differential diagnosis, Rare coexistence of disease or pathology
Piotr J. Nowak A* , Joanna Forycka B , Natalia Cegielska B , Karolina Harendarz B , Małgorzata Wągrowska-Danilewicz B , Marian Danilewicz B , Tomasz Płoszaj B , Maciej Borowiec C , Rafał Wlazeł B , Michał Nowicki DDOI: 10.12659/AJCR.933462
Am J Case Rep 2021; 22:e933462
Table 3. Summary of relevant parameters and main treatment during follow-up.
| Measure | Reference | Weeks after discharge | |||||
|---|---|---|---|---|---|---|---|
| 4 | 12 | 16 | 19 | 23 | 43 | ||
| 24-hour proteinuria | 11.7 | 11.4 | 6.8 | 4.0 | 3.6 | 0.4 | |
| ACR | 1663 | ||||||
| Urine sediment | Bland | Bland | Bland | Bland, single hyaline casts | Bland | Bland, single hyaline casts | Bland |
| Serum creatinine | 101 | 108 | 99 | 119 | 115 | 119 | |
| CKD-EPI eGFR | >60 ml/min/1.73 m | 83 | 77 | 85 | 68 | 71 | 68 |
| Serum albumin | 31–52 g/L | 26.3 | |||||
| Serum potassium | 3.5–5.1 mmol/L | 3.8 | 4.3 | 3.9 | 4.8 | 4.8 | 4.6 |
| Serum sodium | 136–146 mmol/L | 139 | 141 | 142 | |||
| WBC in blood | 4–11×10/µL | 12.6 | 13.5 | 11.4 | 12.0 | 9.5 | 7.3 |
| Platelet count | 15–40×10/µL | 196 | 264 | 235 | 210 | 218 | 234 |
| Blood hemoglobin | 14–18 g/dL | 14.4 | 16.7 | 16.9 | 15.2 | 15.4 | 13.7 |
| Arterial blood pressure | 135/75 | 139/81 | 136/82 | 138/85 | 130/79 | 128/76 | |
| Body weight [kg] | 96 | 99 | 98 | 98 | 99 | 97 | |
| BMI | 18.5–25 kg/m | 27.7 | 28.6 | 28.3 | 28.3 | 28.6 | 28 |
| Prednisone dose [mg/day] | 60 | 60 | 60 | 60→50 | 40 | 5 | |
| Cyclosporine dose [mg/day] | None | None | None | 400 | 400 | 400→300 | |
| Enalapril dose [mg/day] | 20 | 20→30 | 30 | 30 | 30 | 30 | |
| Nebivolol dose [mg/day] | 2.5 | 2.5 | 2.5 | 2.5→5 | 5 | 5 | |
| Kidney re-biopsy | – | – | – | Yes | – | – | |
| ACR – albumin/creatinine ratio; CKD-EPI eGFR – chronic kidney disease epidemiology collaboration estimated glomerular filtration rate; WBC – white blood cells; BMI – body mass index. * Average home blood pressure from previous week; ** patient’s muscle mass was above the average; *** therapy initiation; → dose change. | |||||||