14 May 2022: Articles
Case Series of Successful Intravenous Immunoglobulin (IVIG) Treatment in 4 Pregnant Patients with Severe COVID-19-Induced Hypoxia
Unusual or unexpected effect of treatment, Rare disease
Matthew Geriak A* , Dominic McGrosso D , David J. Gonzalez D , Matthew Dehner A , George Sakoulas ADOI: 10.12659/AJCR.936734
Am J Case Rep 2022; 23:e936734
Table 1. Summary of clinical characteristics of 4 pregnant patients with severe or critical COVID-19 receiving IVIG (Privigen®) therapy.
| Point of pregnancy* | Hospital day IVIG given | Length of hospital stay | Duration of APACH II mechanical ventilation | Score* | A-a Gradient* | BMI* (kg/m2) | CRP* (mg/L) | D-dimer (ng/mL) | PMN/lymph ratio* | Pregnancy outcome | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | 26 wk | 5–7 | 21 days | 11 days (HD 4–14) | 9 | 330 | 34.6 | 85.0 | 896 | 8.0 | NSVD, 37.5 wk |
| 2. | 17 wk | 1–3 | 9 days | 8 days (HD 4–11) | 7 | 598 | 28.0 | 133.2 | 915 | 11.6 | NSVD, 38 wk |
| 3. | 35 wk | 2–4 | 8 days | None | 9 | 310 | 41.1 | 91.6 | 5226 | 4.1 | C-section, 35 wk HD 3 |
| 4. | 35 wk | 1–3 | 12 days | 4 days (HD 1–4) | 16 | 565 | 38.4 | 117.2 | 1378 | 5.8 | C-section, 35 wkHD 1 |
| * At time of IVIG initiation. A-a – Alveolar-arterial; BMI – body mass index; CRP – C-reactive protein (normal level | |||||||||||