29 November 2022>: Articles
Diagnostic Pitfalls of Chylothorax After Dasatinib Treatment of Chronic Myeloid Leukemia
Unknown etiology, Mistake in diagnosis, Adverse events of drug therapy
Ryan L. Kelly E* , Ju Young Bae E , Samantha D’Annunzio E , Francesca Montanari DDOI: 10.12659/AJCR.938319
Am J Case Rep 2022; 23:e938319
Table 2. Review of cases associated with Dasatinib-induced chylothorax and outcomes.
Age | Gender | Months on dasatinib | Previous therapy | Treatment | Dasatinib status | Recurrence of PE | Citation Huang et al |
---|---|---|---|---|---|---|---|
40 | Female | 40 | Imatinib | Diuretics + steroids | Stopped | None | []3 |
73 | Female | 12 | None | Diuretics + initiation of herbal medicine, goreisan, after trialing bosutinib and imatinib) | Stopped (changed to imatinib) | None | Sasaki et al []4 |
63 | Female | 48 | None | Nebulizers, steroids, doxycycline, ceftriaxone, and lasix | Stopped (changed to nilotinib) | Recurrences until switched to nilotinib | Al-Abcha et al []5 |
69 | Male | 10 | Imatinib and Nilotinib | Change to bosutinib | Stopped (changed to bosutinib) | None | Baloch et al []6 |
5 | Female | 10 | Imatinib | Complete stopping of dasatinib | Stopped | None | Hickman et al []7 |
51 | Male | 50 | Imatinib | Steroids + nilotinib | Stopped (switched to nilotinib) | None | Hsu et al []8 |
71 | Woman | 2 | Imatinib | Thoracentesis, dose reducing dasatinib | Dose reduction | Reduced incidence, not complete resolution | Ferreiro et al []9 |
47 | Male | 8 | Imatinib | Thoracentesis, diuretics, supportive tx | Continued | Unclear | Yang et al []10 |
46 | Male | 19 | Imatinib | Discontinue dasatinib, thoracentesis, diuretics, + steroids | Stopped | Unclear | Yang et al []10 |
49 | Male | 26 | Imatinib | Dasatinib temporarily stopped, ligation of thoracic duct, parenteral nutrition support | Stopped for 48 hrs, now back on dasatinib | Unclear | Yang et al []10 |
71 | Male | 6 | Imatinib | Dasatinib stopped | Stopped | None | Chen et al []11 |
63 | Woman | 12 | None | Thoracentesis, prednisone, imatinib | Stopped (switched to imatinib) | None | Molina et al []12 |