Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common

Jeffrey J. Li; Shirley Tan; Takumi Kawashita; Christian A. Tagle; Farbod Farmand

doi:10.12659/AJCR.939034

23 January 2023: Articles

Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common

Unusual clinical course, Unexpected drug reaction

Jeffrey J. Li ^A* , Shirley Tan ^B , Takumi Kawashita ^B , Christian A. Tagle ^B , Farbod Farmand ^A

DOI: 10.12659/AJCR.939034

Am J Case Rep 2023; 24:e939034

Authors information Article notes Copyright and License information

Background Case Report Discussion Conclusions References:

View HTML version

Table 1. Urine osmolality after desmopressin trials. First desmopressin trial resulted in a 343% increase in urine osmolality. Second desmopressin trial resulted in a 187% increase in urine osmolality. Increase in urine osmolality by at least 50% after desmopressin administration is diagnostic of central diabetes insipidus.

	Urine osmolality before desmopressin administration	Urine osmolality after desmopressin administration
Desmopressin trial 1	74 mOsm/kg	254 mOsm/kg
Desmopressin trial 2	194 mOsm/kg	362 mOsm/kg

Back to the Article

Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common

Your Privacy