29 July 2023: Articles
Botulinum Toxin as an Adjunctive Therapy for Immobilization of a Distal Humerus Fracture in Parkinson’s Disease-Associated Psychosis: A Case Report
Unusual clinical course, Unusual or unexpected effect of treatment
Justin Lapow E , Jacob Hirth E , Avinesh Agarwalla A , David S. Wellman A*DOI: 10.12659/AJCR.939680
Am J Case Rep 2023; 24:e939680
Table 1. Previous literature on botulinum toxin injections as an adjunct for fracture treatment.
| Author | Study type | Subject(s) | Age(s) | Fracture | Internal Fixation (Y/N) | Botulinum toxin injection site(s) | Outcomes |
|---|---|---|---|---|---|---|---|
| Tukel et al, 2020 []14 | Animal study | 48 male rabbits | N/A | Unilateral mandible | Y | Masseter muscles | Improved fracture healing after 21 days compared to saline-injected controls |
| Chen and Thalayasingam, 2010 []15 | Case report | One male with motor tic disorder | 11 years | Left clavicle | Y | Pectoralis major, anterior deltoid, trapezius, and levator scapulae muscles | Cessation of motor tics for 3–4 months with successful healing of the fracture during that time |
| Aydin et al, 2012 []16 | Animal study | 18 rats | N/A | Bilateral femur fractures | Y | Unilateral right femoral region | Increased biomechanical and histologic healing with decreased callous diameter was found on the injected side 28 days after administration |
| Canter et al, 2007 []17 | Case series | Six male and four females | 3–51 years (mean 29.4 years) | Unilateral subcondylar mandible or condylar neck | N | Masseter, anterior fibers of the temporalis, medial and lateral pterygoid muscles | Successful healing, with no loss of reduction. Return of muscular contractions after 3–4 months |
| Akbay et al, 2014 []18 | Case report | One male | Three years | Condylar neck of the left mandible | N | Masseter, temporalis, and pterygoideus medialis muscles | Fusion of mandibular condyle was achieved after one month |
| Shin et al, 2018 []19 | Retrospective cohort | Eight patients (six males and two females) received botulinum toxin and eight patients (four males and four females) received no injections | 18–34 years (mean 22.25 years) | bilateral sagittal split ramus osteotomy | Y | Bilateral masseter muscles | Botulinum toxin injections resulted in a lower rate of mandibular plate fracture than those who received no injections |
| Shilt et al, 2021 []20 | Retrospective case series | Five male patients | Ages 12–17 years (mean 14) | Proximal hamstring avulsion of the ischium | Y (all except one patient) | Hamstring muscles | Radiograph confirmed healing of avulsion fractures in all patients with a return to previous activity at a mean of 32 weeks |
| White et al, 2022 []21 | Case report | One woman | 73 years old | Periprosthetic scapular spine fracture six months reverse shoulder arthroplasty | Y | Deltoid muscle | Fracture union attained at three months with excellent return to function at one year |
| Hao et al, 2012 []28 | Animal study | 44 rats | N/A | Osteotomy of bilateral femurs | Y | Unilateral quadriceps | No mature osseous callouses or woven bone on the botulinum toxin treated side after eight weeks |