16 October 2023: Articles
Bilirubin Elevation Caused by Naproxen Overdose: A Case Report Highlighting Laboratory Interference
Unusual clinical course, Unexpected drug reaction
Olivia Heutlinger D* , Tobin Mathew D , Dylann Fujimoto D , Vishnu Bharani E , Rebecca Yamarik D , Samuel Baz EDOI: 10.12659/AJCR.941267
Am J Case Rep 2023; 24:e941267
Table 2. Differential diagnosis of indirect hyperbilirubinemia [18].
| Mechanism of hyperbilirubinemia | Examples |
|---|---|
| Intravascular hemolysis | Glucose-6-phosphate dehydrogenase (G6PD) deficiency |
| Sickle cell anemia | |
| Thalassemia | |
| Hereditary spherocytosis | |
| Extravascular hemolysis | Hematoma breakdown |
| Splenic sequestration crisis | |
| Acquired hemolysis | Autoimmune hemolytic anemia |
| Hemolytic-uremic syndrome | |
| Thrombotic thrombocytopenic purpura | |
| Infection (malaria, babesiosis) | |
| Drug-induced | Phenytoin |
| Probenecid | |
| Ketoconazole | |
| Protease inhibitors | |
| Dapsone | |
| Quinidine | |
| Antibiotics (rifampicin, cephalosporins, penicillins, nitrofurantoin) | |
| Genetic disorders | Gilbert syndrome |
| Crigler-Najjar syndromes | |
| Lucy-Driscoll syndrome | |
| Impaired hepatic bilirubin uptake | Congestive heart failure |
| Portosystemic shunts | |
| Chronic liver disease | |
| Miscellaneous | Wilson disease |
| Thyrotoxicosis | |
| * Typically symptomatic. |