An Elusive Diagnosis: Diffuse Large B-Cell Lymphoma Masquerading as Acute Liver Failure with Persistent Lactic Acidosis

23 October 2023: Articles

Challenging differential diagnosis, Rare disease

Prabasha Weeraddana ^F* , Oluwole Odujoko ^F , Shubhneet Bal ^F , Niwanthi Mannapperuma ^F , David Maslak ^E , Gunjan Gupta ^A

DOI: 10.12659/AJCR.941270

Am J Case Rep 2023; 24:e941270

Table 2. Cases reported to date of acute liver failure secondary to infiltration of the liver by non-Hodgkin lymphoma.

	Authors	Year of publication	Patient’s age (yrs)	Pt’s sex	Diagnostic imaging performed	Tissue biopsy performed	Pt’s outcome
1	Yoshikawa et al	1998	75	M	CT: hepatosplenomegaly	Liver/spleen necropsy	Dead
2	Lettieri et al	2003	48	M		BM/liver biopsy	Dead
3	Haider et al	2008	53	F	CT: splenomegaly	Liver biopsy	Alive
4	Ahmadi et al	2014	62	M	CT: hepatosplenomegaly, LN	BM/liver biopsy	dead
5	Siba et al	2014	71	M	US: fatty liver, splenomegaly	LN biopsy	Dead
6	Kapuria et al	2015	57	M	CT: hepatosplenomegaly	Liver biopsy	Alive
7	Grille et al	2015	74	F	hepatomegaly	Liver biopsy	Dead
8	Omori et al	2016	60	M	hepatosplenomegaly	BM biopsy	Alive
9	Sakae et al	2016	66	M	CT: hepatosplenomegaly	Autopsy	Dead
10	Patel et al	2017	57	M	CT: splenomegaly, hepatic steatosis	Liver biopsy	Dead
11	El Nouwar et al	2018	55	F	US, CT&MRCP: hepatomegaly	BM biopsy	Dead
12	Shibata et al	2019	33	F	US,CT: atrophic liver, splenomegaly, LNs	Gastric biopsy	Alive
13	Kubo et al	2020	87	M	CT: mild splenomegaly	Autopsy	Dead
14	Penn et al	2020	51	M	CT: splenomegaly	Liver, LN biopsies	Dead
15	Hafner et al	2020	75	F	CT: lymphadenopathy	LN biopsy	Dead
16	Rao et al	2021	65	M	CT: hepatomegaly, LNs	Liver biopsy	Alive
17	Gkoufa et al	2022	72	F	CT: No specific finding	BM/liver biopsy	Dead