08 December 2023: Articles
Unusual Case of Splenic Metastasis in Adenosquamous Carcinoma of the Cervix Uteri: Diagnosis and Treatment Considerations
Unusual clinical course
Gilbert Georg Klamminger A* , Caroline Burgard B , Florian Rosar B , Katrin Altmeyer B , Maciej Malinowski B , Meletios P. Nigdelis A , Phillip Rolf Stahl C , Erich Franz Solomayer A , Bashar Haj Hamoud ADOI: 10.12659/AJCR.941600
Am J Case Rep 2023; 24:e941600
Table 1. Synopsis of published clinical cases of solitary splenic metastasis in patients with diagnosed primary carcinoma of the cervix uteri.
| Author/Year of publication [ref] | Primary tumor entity/FIGO | Patient age | Metastatic symptoms | Diagnostics | Primary treatment | Secondary treatment of metastasis |
|---|---|---|---|---|---|---|
| Kumar et al [] (2022)12 | SCC/ns | 46 | ns | PET scan, CT scan | Surgery, radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| AlQattan et al [] (2021)7 | Adenocarcinoma/IIIB | 54 | ns | MRI | Radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| Liu et al [] (2021)13 | SCC/IIB | 49 | Anorexia, abdominal distension | CT scan; carcinoembryonic antigen, CA125, CA199 antigen levels | Radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| Shankar et al [] (2020)14 | SCC/IVA | 55 | ns | PET scan, CT-guided biopsy | Radiotherapy, chemotherapy | Surgery (splenectomy) |
| Filipescu et al [] (2018)15 | SCC/ns | 30 | ns | ns | Neoadjuvant radiochemotherapy, surgery | Surgery (splenectomy) |
| Bacalbasa et al [] (2017)16 | SCC/IIB | 31 | ns | Diagnostic surgery | Neoadjuvant chemotherapy & radiotherapy, surgery | Surgery (splenectomy), adj. chemotherapy |
| Applebaum et al [] (2017)17 | SCC/ns | 46 | ns | PET scan, CT scan | Surgery, radiotherapy, | Surgery (splenectomy) |
| Dixit et al [] (2016)5 | SCC/IIA | 46 | Fever and anorexia | PET scan, CT scan | Surgery, radiotherapy, chemotherapy | Surgery (splenectomy, segmental resection of ileum, omentectomy and partial peritonectomy), adj. chemotherapy |
| Villalón-López et al [] (2014)8 | Adenocarcinoma/IB | 76 | Abdominal pain | CT scan, CA-125 antigen levels | Surgery, radiotherapy | Surgery (splenectomy), adj. chemotherapy |
| Taga et al [] (2014)4 | Undifferentiated carcinoma/IIB | 49 | ns | CT scan, explorative laparotomy | Radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| Zamurovic et al [] (2011)18 | Planocellular carcinoma/IB | 40 | Abdominal pain, rice water stools | Ultrasonography, CT scan | Surgery, radiotherapy | Surgery (splenectomy) |
| Di Donato et al [] (2010)19 | SCC/IVA | 30 | Abdominal pain | CT scan, PET scan, SCC antigen levels | Neoadjuvant chemotherapy, surgery | Surgery (splenectomy, distal pancreatectomy, and partial gastric resection), adj. chemotherapy |
| Kim et al [] (2008)9 | SCC/IIB | 54 | No abdominal discomfort/mass | SCC antigen levels, CT scan, PET scan | Radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| Kim et al [] (2008)9 | Adenocarcinoma/IIB | 46 | No abdominal discomfort/mass | MRI | Radiotherapy, chemotherapy | Surgery (splenectomy), adj. chemotherapy |
| Bhardwaj et al [] (2008)20 | SCC/IIB | 50 | Painful abdominal mass, intermittent fever | Ultrasonography, explorative laparotomy | Radiotherapy | Surgery (splenectomy) |
| Komatsu et al [] (2004)21 | SCC/ns | 52 | ns | CT scan | Surgery | Surgery (splenectomy) |
| Goktolga et al [] (2004)22 | SCC/IIA | 45 | Abdominal fullness and pain | CT scan and fine needle aspiration | Surgery and adjuvant radiotherapy | Explorative laparotomy; chemotherapy due to multifocal tumor invasion |
| Pang LC [] (2004)23 | SCC/IIA | 50 | ns | SCC antigen levels, CT scan, MRI, PET scan | Surgery and adjuvant radiotherapy | Surgery (splenectomy), adj. chemotherapy |
| Carvalho et al [] (1997)24 | SCC/IIB | 47 | Pain of regio hypochondriaca; weight loss | Explorative laparotomy | Radiotherapy | Chemotherapy |
| Valls et al [,] (1992)7 | Adenocarcinoma/ns | 55 | Abdominal pain | CT scan | Surgery, radiotherapy | Surgery (splenectomy) |
| Campagnutta et al [] (1992)11 | Adenocarcinoma/ns | 47 | Abdominal pain | CT scan, scintigraphy | Surgery, radiotherapy | Surgery (splenectomy, adj. chemotherapy |
| Klein et al [,] (1987)3 | SCC/IIB | 28 | Abdominal pain | CT scan | Radiotherapy | Surgery, chemotherapy |
| Brufman et al [,] (1977)3 | SCC/IB | 43 | ns | ns | Surgery | Chemotherapy |
| CT – computerized tomography; MRI – magnetic resonance imaging; ns – not specified; PET – positron emission tomography; SCC – squamous cell carcinoma. Additive splenic metastases as part of a disseminated disease were not considered. For an in-depth analysis of splenic metastasis in case if squamous cell carcinoma of the cervix uteri, see also the comprehensive overview of Marcu et al [] * Spanish article with English abstract available. ** Japanese article with English abstract available. *** Italian article with English abstract available. # Article in Hebrew. | ||||||