05 February 2024: Articles
Pharmacogenetic Analysis of an 8-Year Old Girl with Reye Syndrome Associated with Use of Naproxen
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Unexpected drug reaction, Rare disease, Clinical situation which can not be reproduced for ethical reasons
Byungwook Kim A , Joo-Youn Cho D , Ildae Song ** , Jaeseong Oh **DOI: 10.12659/AJCR.942242
Am J Case Rep 2024; 25:e942242
Table 2. Pharmacogenetic test results for genes involved in the metabolism of naproxen.
| Genes | Allele | Functional change |
|---|---|---|
| *1L/*1L | No functional change | |
| *1/*1 | Extensive metabolizer | |
| *1/*6 | Intermediate metabolizer | |
| *1/*2 | May have decreased metabolism | |
| Wild type | No functional change | |
| *1/*2 | May have decreased metabolism | |
| Genes known to be involved in the metabolism of naproxen are presented. Allele results are combined result of single-nucleotide polymorphisms of respective genes and represent phenotypes. | ||