02 January 2005 : Original article
Chronic hepatitis with diffuse steatosis and slight fibrosis related to etretinate therapy
Leonardo Calza, Gabriella Verucchi, Luciano Attard, Roberto Manfredi, Francesco ChiodoCase Rep Clin Pract Rev 2005; 6:20-23 :: ID: 16402
Abstract
Summary
Background: Etretinate, an aromatique retinoid, has been used to treat severe or treatment-resistant psoriasis, and has been found to cause transient, mild abnormalities of liver function tests in about
one third of patients. Significant liver disease may occur in a few patients, ranging from acute hepatitis to chronic, aggressive hepatitis and cirrhosis.
Case report: A case of chronic hepatitis associated with steatosis and fibrosis in a 39-year-old male patient treated with etretinate for severe palmoplantar psoriasis is reported. Results of periodical liver
function tests were still normal 4 and 8 weeks after initiation of etretinate therapy, but became abnormal 12 weeks later, when asthenia was referred and liver enzyme levels were found to
be elevated. The liver enzyme levels gradually decrease after therapy with retinoid was stopped, but these biochemical abnormalities were still evident 5 years later. The liver biopsy showed small inflammatory cell infiltrates, in addition to initial, slight fibrosis, steatosis, and
ductular proliferation, and ultrastructural study of biopsy specimens demonstrated diffuse abnormalities, consistent with a drug-related, chronic liver damage.
Conclusions: Etretinate therapy may lead to a wide spectrum of hepatotoxic reactions, ranging from nonspecific reactive hepatitis to cirrhosis, and requires a close monitoring of liver function during
the first 6 months.
Keywords: etretinate, aromatic retinoid, Psoriasis, chronic hepatitis, steatosis, Fibrosis
37
In Press
05 Mar 2024 : Case report
Transformation of Severe Aplastic Anemia into Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell ...Am J Case Rep In Press; DOI: 10.12659/AJCR.943801
14 Mar 2024 : Case report
Potential Indicators of Intestinal Necrosis in Portal Venous Gas: A Case Report of an 82-Year-Old Woman on ...Am J Case Rep In Press; DOI: 10.12659/AJCR.942966
05 Mar 2024 : Case report
Simultaneous Transcatheter Closure of a Ventricular Septal Defect and Pulmonary Valvuloplasty: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942032
06 Mar 2024 : Case report
Successful Healing of Periapical Pathology with Partial Pulpotomy in a Mature Permanent Molar: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942937
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250