01 January 2002
Combination of pamidronate and thalidomide in the therapy of treatment-resistantmultiple myeloma.
Wojciech Baran, Hanna Ciepłuch, Andrzej HellmannMed Sci Monit 2002; 8(4): PI31-36 :: ID: 420859
Abstract
BACKGROUND: Bisphosphonates inhibit the activity of osteoclasts and demonstrateantitumor effect, involving induction of plasmocyte apoptosis, blocking of angiogenesis, stimulationof Tgd lymphocytes and inhibition of metalloproteinases. Bisphosphonates combined with thalidomide, adrug possessing confirmed anti-myeloma activity, seem to have potential favorable effect in patientswith treatment-resistant multiple myeloma with advanced osteolytic lesions. MATERIAL/METHODS: 13 patientswith treatment-resistant multiple myeloma with advanced osteolytic lesions received combined pamidronateand thalidomide therapy. All the patients underwent detailed clinical and laboratory control once a month.Pamidronate was used at 90 mg i.v. dose administered at 4-week intervals, and thalidomide at doses escalatedfrom 200 mg/d in the first week to 400 mg/d after 3 weeks of the therapy. The mean duration of treatmentwas 12 weeks with a range of 3 to 36 weeks. RESULTS: 7 patients (53%) receiving pamidronate and thalidomidetherapy demonstrated good response involving at least 25% reduction of monoclonal protein levels in comparisonwith baseline. All these patients reported improvement of osteodynia symptoms, and 3 of them - theircomplete regression. 70% patients experienced side effects (dizziness, constipation, somnolence, polyneuropathy)due to thalidomide administration CONCLUSIONS: Good response to combined pamidronate and thalidomidetherapy can be expected in at least 50% of patients with treatment-resistant multiple myeloma with advancedosteolytic lesions.
Keywords: Aged, 80 and over, Angiogenesis Inhibitors, Antineoplastic Combined Chemotherapy Protocols, Constipation, Diphosphonates, Disorders of Excessive Somnolence, Dizziness, Multiple Myeloma, Myeloma Proteins, Osteolysis, Pain, Remission Induction, thalidomide
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Effects of Thermal Insulation on Recovery and Comfort of Patients Undergoing Holmium Laser LithotripsyMed Sci Monit In Press; DOI: 10.12659/MSM.942836
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952