Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


Get your full text copy in PDF

Myelonecrosis – clinicopathological significance of a rare bone marrow lesion

Debdatta Basu, Parasappa Yaranal

CaseRepClinPractRev 2005; 6:261-264

ID: 429695

Background: Myelonecrosis is a rare ante-mortem finding and reported in a wide range of disorders.
Case Report: Seven cases of myelonecrosis were diagnosed in a period of four years, accounting for 0.58% of bone marrow trephine biopsies done in this period. A detailed clinical and hematological profile
was studied in each case.The diseases associated with marrow necrosis were varied and included metastatic carcinoma, acute leukaemia, post chemotherapy in a case of non-Hodgkin’s lymphoma and tuberculosis.Three patients had acquired immunodeficiency syndrome. Thrombocytopenia, anemia and leucoerythroblastic blood picture were common hematological abnormalities. Three patients died shortly after the diagnosis was made.
Conclusions: Myelonecrosis or bone marrow necrosis is an uncommon finding in bone marrow biopsies.Presence of necrosis in marrow is usually associated with an underlying disease and has a poor prognosis.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree