H-Index
17
Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
MSMbanner

Annals
ISI-Home

Get your full text copy in PDF

Role of angiogenesis and growth factors in chronic peptic ulcer disease

Krzysztof Pałgan, Zbigniew Bartuzi, Izabela Pałgan, Anna Szaflarska-Szczepanik, Andrzej Dziedziczko

CaseRepClinPractRev 2002; 3(3):194-199

ID: 474516


The development of new blood vessels in humans in the postembryonal period may be physiological (the follicular phase of the menstrual cycle, the formation of placenta, wound healing) or accompany such pathological
processes as neoplasms, proliferative retinopathy occurring in diabetes, chronic peptic ulcer disease, ulcerative colitis, psoriasis, atheromatosis and rheumatoid diseases. Healing of chronic gastric and duodenal ulcers is assisted by growth factors, which stimulate the development
of granulation tissue. The growth factors involved in ulcer healing include basic fibroblast growth factor (bFGF), transforming growth factor-α (TGF-α) epidermal growth factor (EGF) and platelet derived growth factor (PDGF). The aforementioned factors stimulate migration and proliferation of vascular endothelial cells, and enhance mitotic divisions of fibroblasts – cells playing an important role in ulcer healing process. Both granulation tissue development and neoangiogenesis are enhanced by nitric oxide (NO/EDRF), which improves blood supply to the ulcer margins. The paper discusses also the effect of some drugs and tobacco smoking on angiogenesis in chronic peptic ulcer disease.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree