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The latest revelation of the HIV1 natural history infection has made more aspects of the virus entry into cells more comprehensible. It is described as a multistage process with a key role of receptors and coreceptors. Succeeding binding of the structures launches a conformational casacade leading to virus-cell membrane fusion. Isolation of particles effectively blocking the process could enable creating new classes of antiretroviral drugs with a completely different way of affecting the virus. Certain prototype structures have already resulted to be successful - mostly according to in vitro research. However, further studies concerning in vivo analysis-which has partly been pursued-seems to be very promising, as well.