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Rapid progression of Wegener’s Granulomatosis to therapy related Myelodysplastic Syndrome and Acute Myelomonocytic Leukemia: case report

Christos Bomboris, George Andreopoulos, Nora-Athina Viniou, Stefanos Koyndoyris, Nikolaos Kaklamanis, Maria Moschogianni, John Dalamagas, Eleni Variami, Anastasios Andreopoulos, George Vaiopoulos, John Meletis, Gerasimos Pangalis

Am J Case Rep 2008; 9:74-77

ID: 744378

Background: Treatment of Wegener’s Granulomatosis (WG) with Cyclophosphamide still remains a problem for developing secondary malignancies.
Case Report: A 64 year old patient diagnosed with WG in May 2004, developed RAEB I MDS and Acute Myelomonocytic Leukemia after treatment with relatively low dose of Cyclophosphamide 26 months after diagnosis of rheumatic disease.
Conclusions: We suggest close hematological monitoring of WG patients treated with alkylating agents for early diagnosis of secondary, therapy related, disorders.

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