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Disseminated strongyloidiasis following high-dose prednisolone administration

Afshin Shafaghi, Kambiz Akhavan, Hadi Hajizade, Fariborz Mansour-Ghanaei

Am J Case Rep 2010; 11:74-77

ID: 878549

Background: Strongyloides stercoralis is a common intestinal nematode that affects 30–100 million people worldwide. It is endemic in Guilan province and especially affects the rural population.
Case Report: We report the case of a 65-year-old woman living in Guilan province of Iran with a history of diabetes mellitus who was treated with high-dose prednisolone for temporal arteritis. Undiagnosed infestation by this nematode led to disseminated strongyloidiasis and Gram-negative sepsis. Fortunately, early diagnosis and prompt therapy with a proper anthelmintic drug as well as supportive care led to an acceptable outcome.
Conclusions: All patients who are candidates for immunosuppressive therapy or who are planned to receive steroid should be evaluated for strongyloidiasis. Although a stool exam is the first and simplest test for this purpose, it may be negative for the parasite despite a large parasitic burden. Thus physician awareness should be emphasized and a high index of suspicion required to diagnose this ominous condition by further evaluation (serology, evaluation of duodenal aspirate, and endoscopy with biopsy).

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