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Pseudallescheria Boydii pneumonia in an immunocompetent host

Gustavo Cumbo-Nacheli, Jorgelina de Sanctis, David Holden

Am J Case Rep 2012; 13:163-165

DOI: 10.12659/AJCR.883276

Background:    Pseudallescheria boydii pneumonia is rarely reported among immunocompetent patients.
    Case Report:    We report a case of a 62 year old white female with pseudallescheria boydii pneumonia. The patient was non-immunocompromised, had a history of mycobacterium avium complex (MAC) infection prior to presentation. After successful response to initial antitubercular therapy, the patient developed recurrent symptoms and bibasilar nodular infiltrates. Second line therapy for MAC failed to improve symptomatology. Pseudallescheria boydii pneumonia was diagnosed from a bronchoscopic biopsy. Treatment with voriconazole resolved her symptomatology and radiological infiltrates.
    Conclusions:    This case highlights the importance of a high index of suspicion for superimposed fungal infections in patients who are refractory to medical treatment of bacterial pneumonitis such as MAC. Further diagnostic interventions are encouraged when insufficient clinical improvement is observed. Prompt initiation of an antifungal regimen is warranted.

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