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Georg Richter, Holger Heidersdorf, Dieter Hirschfeld, Friedhelm Krebbel
(Institute of Pathology, Hameln, Germany)
Am J Case Rep 2016; 17:133-136
The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.
CASE REPORT: A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.
CONCLUSIONS: The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.