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Cytomegalovirus Colitis and Subsequent New Diagnosis of Inflammatory Bowel Disease in an Immunocompetent Host: A Case Study and Literature Review

Tipu V. Khan, Carla Toms

(Ventura County Medical Center, Family Medicine Residency Program, University of California, Los Angeles David Geffen School of Medicine, Ventura, CA, USA)

Am J Case Rep 2016; 17:538-543

DOI: 10.12659/AJCR.898005

BACKGROUND: Infection with gastrointestinal cytomegalovirus in an immunocompetent host is a rather rare occurrence in the literature. There are a few reports of gastrointestinal infection in the immunocompetent who are then subsequently given a new diagnosis of inflammatory bowel disease. It is speculated that the initial cytomegalovirus colitis infection triggers the onset of inflammatory bowel disease.
CASE REPORT: Herein we report a case of cytomegalovirus colitis and new diagnosis of inflammatory bowel disease identified in a 40-year-old immunocompetent adult man who presented with gastrointestinal symptoms and disseminated cytomegalovirus infection requiring anti-viral therapy, which successfully treated the episode of cytomegalovirus infection. He then went on to have persistent symptomatic inflammatory bowel disease confirmed by pathology.
CONCLUSIONS: In this paper we will review the literature and explore the rare case of cytomegalovirus colitis in the immunocompetent host and discuss the pathology, physiology, diagnosis, and treatment of cytomegalovirus colitis.

Keywords: Antiviral Agents - therapeutic use, Adult, Biopsy, Cytomegalovirus - genetics, Cytomegalovirus Infections - drug therapy, Immunocompromised Host, Inflammatory Bowel Diseases - immunology, RNA, Viral - analysis

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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