Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST


Get your full text copy in PDF

Breast Implant-Associated Anaplastic Large Cell Lymphoma (ALCL): A Case Report

Sevan Evren, Thaer Khoury, Vishalla Neppalli, Helen Cappuccino, Francisco J. Hernandez-Ilizaliturri, Prasanna Kumar

(Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA)

Am J Case Rep 2017; 18:605-610

DOI: 10.12659/AJCR.903161

BACKGROUND: Anaplastic large cell lymphomas (ALCL) are a rare type of primary breast lymphoma. The association between breast implants and ALCL was first described in 1997 and since then 34–173 cases have been presented. The annual incidence of breast implant-associated ALCL (BI-ALCL) is 0.1–0.3 per 100 000 women who undergo breast reconstruction, and cases are often underreported due to the rarity of these tumors. BI-ALCL arises from the inflammatory T cells surrounding the fibrous capsule, and most tumors are in situ.
CASE REPORT: Here, we present the case of a 51-year-old woman with ALCL following bilateral silicone breast implants. The patient presented with breast enlargement and tenderness 9 years following reconstructive surgery. Imagining studies showed fluid collection surrounding the affected breast implant. Staging studies and histocytopathology examination confirmed the presence BI-ALCL without capsular invasion or metastasis. Complete surgical excision was performed. The patient continues to be in complete remission.
CONCLUSIONS: Due to the rarity of these tumors, establishing the diagnosis of BI-ALCL can be challenging and requires a multidisciplinary approach. Clinicians should be aware of the relationship between breast implants and BI-ALCL.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree