H-Index
14
Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Logo


Get your full text copy in PDF

Short-Term High-Dose Steroid Therapy in a Case of Rhabdomyolysis Refractory to Intravenous Fluids

Fnu Zarlasht, Mashal Salehi, Alamgir Sattar, Mohammad Abu-Hishmeh, Muzammil Khan

(Department of Medicine, New York City Health + Hospitals, Lincoln, Bronx, NY, USA)

Am J Case Rep 2017; 18:1110-1113

DOI: 10.12659/AJCR.905196


BACKGROUND: Rhabdomyolysis is a syndrome characterized by skeletal muscle breakdown, that involves the release of intracellular contents into the circulation, including creatine kinase (CK), myoglobin, electrolytes, organic acids, and purines. Causes of rhabdomyolysis include trauma, exertion, drugs, and toxins (including alcohol), and electrolyte abnormalities. The treatment of rhabdomyolysis is to remove the cause and use intravenous (IV) fluids. When this treatment strategy fails to work, high-dose IV steroids may be used.
CASE REPORT: We present a case of rhabdomyolysis following the use of 3,4-methylenedioxy-methamphetamine (MDMA) or ‘ecstasy’ with hypophosphatemia, which was found to be refractory to intravenous hydration. In this case, pulsed dosing of steroid therapy was found to be effective.
CONCLUSIONS: Rhabdomyolysis that is refractory to treatment with IV fluids may respond to a short-term, high-dose course of IV steroids.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree