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Severe Fetal Distress and Placental Damage might be Associated with High Troponin I (cTnI) Levels in Mothers

Irene Turrini, Flavia Sorbi, Viola Ghizzoni, Luca Mannini, Massimiliano Fambrini, Alessandro Terreni, Elisabetta Projetto, Francesca Castiglione, Ivo Noci

(Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy)

Am J Case Rep 2018; 19:194-198

DOI: 10.12659/AJCR.906617


BACKGROUND: Troponin I is the gold standard for the diagnosis of adult acute coronary syndrome. Although it is known that a hypoxic fetus may produce cTnI, fetal cTnI passage in maternal blood has never been documented.
CASE REPORT: We report a case where the rise of cTnI in the blood of a pregnant woman was not related to maternal heart disease. Instead, it might be suggestive of a fetal cardiac origin, as there was a severe placental insufficiency with a fetal intrauterine growth restriction.
CONCLUSIONS: This study suggests that the rise of cTnI in maternal blood in a cardiovascular healthy pregnant woman might have a fetal origin. After having excluded any maternal causes, cTnI elevation could be explained with the transfer of fetal cTnI through an injured placenta.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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