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Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus

Roger A. Fecher, Brittany A. Leader, Yash Patil, Randall Butler

(Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA)

Am J Case Rep 2018; 19:482-485

DOI: 10.12659/AJCR.908252


BACKGROUND: Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5–5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma.
CASE REPORT: Here, we present a case of tonsillar SmCC that presented as combined SmCC-squamous cell carcinoma in a cervical lymph node, raising the possibility that the SmCC-component represents disease progression.
CONCLUSIONS: This case lends further support to the importance of HPV in the development of oropharyngeal SmCC and suggests a mechanism of disease progression.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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