H-Index
14
Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Logo


Get your full text copy in PDF

Multiple Myeloma in a Patient with Focal Segmental Glomerulosclerosis: A Case Report

Ashraf O. Oweis, Sameeha A. Al Shelleh, Najla Aldaoud, Osama Mohammed Alshari, Mousa A. Al-Abbadi

(Division of Nephrology, Department of Internal Medicine, Jordan University of Science and Technology, Irbid, Jordan)

Am J Case Rep 2018; 19:946-950

DOI: 10.12659/AJCR.909696


BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome in adults, which can be primary, or secondary to various causes. Unlike membranous nephropathy, FSGS is less likely to be associated with malignancy. Few cases have been reported of the occurrence of FSGS with hematological malignancies like multiple myeloma (MM).
CASE REPORT: A 48-year-old man presented with nephrotic syndrome and renal impairment and was diagnosed with primary FSGS after kidney biopsy, which showed a segmental scar with diffuse effacement of foot processes on electron microscopy. Treatment with steroids reduced proteinuria and stabilized the renal function. A few months later, the patient presented with acute Kidney Injury, bone pain, and anemia. A diagnosis of MM was made based on the bone marrow biopsy. Treatment of MM decreased proteinuria and improved renal function.
CONCLUSIONS: There is an association between FSGS and MM through an unclear mechanism.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree