Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


Get your full text copy in PDF

Massive Pulmonary Embolism as the Initial Presentation of Acromegaly: Is Acromegaly a Hypercoagulable Condition?

Anam M. Elarabi, Eman Mosleh, Laith I. Alamlih, Mutaz M. Albakri, Wanis H. Ibrahim

(Department of Pulmonology, Hamad Medical Corporation, Doha, Qatar)

Am J Case Rep 2018; 19:1541-1545

DOI: 10.12659/AJCR.911572

BACKGROUND: The clinical presentation in acromegaly is usually insidious, with headaches or visual disturbances being the most common symptoms. Previous studies have shown higher fibrinogen levels, lower protein C and S activity values, and enhanced platelet function in patients with acromegaly compared to a normal population. Nevertheless, the link between hypercoagulability and acromegaly is often overlooked and rarely reported in the literature.
CASE REPORT: We report a case of a young man with a massive pulmonary embolism as the initial presentation of acromegaly. Extensive workup excluded other causes of thrombophilia. Furthermore, the diagnosis of acromegaly was confirmed by the patient’s clinical features as well as laboratory and radiological testing. A literature review on the link between hypercoagulability and acromegaly was performed.
CONCLUSIONS: This case report shed light on hypercoagulability as an under-recognized serious complication of acromegaly and paves the road for future studies on this topic.

Keywords: acromegaly, Embolism and Thrombosis, Pulmonary Embolism, Thrombophilia

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree