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Gholamreza Askari, Amir Reza Moravejolahkami
(Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran)
Am J Case Rep 2019; 20:548-550
To relieve the signs and symptoms of anterior uveitis (AU), an ocular manifestation of Behcet’s syndrome, we prescribed a synbiotic supplementation (probiotics and prebiotics) for a 49-year-old woman.
CASE REPORT: Seven strains of bacteria - Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus bulgaricus, each 10⁸ colony-forming units (CFU) - and fructo-oligosaccharide (FOS; 100 mg) were given as a capsule 2 times per day.
After 7-month treatment, AU was improved and serum inflammatory markers - C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), and estimated sedimentation rate (ESR) - were suppressed. Now, if a mild AU attack occurs, the problem is resolved by treatment with 1 gtt (from the Latin “guttae”, meaning drops) eye drop (prednisolone 1%) for 1 week.
CONCLUSIONS: Synbiotic supplementation may contribute to treating AU, which is one of the most disastrous manifestations of BS, by controlling the proinflammatory processes.