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Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases

Flávia Luiza Marin, Henrique Pereira Sampaio

(Postgraduate Program in Pathophysiology in Medical Clinic, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil)

Am J Case Rep 2019; 20:1094-1103

DOI: 10.12659/AJCR.916178

BACKGROUND: With the advent and advancement of autoantibodies, there has been progress in the diagnosis, prognosis, and treatment of rheumatologic diseases. Antisynthetase syndrome (ASS) is a great example of a disease that initially was described as arthritis, myositis, interstitial lung disease, mechanic’s hands, Raynaud’s phenomenon, and fever in the presence of the anti-JO-1 antibody, but nowadays it presents with a different spectrum related to new antibodies.
CASE REPORT: We describe 4 patients with antisynthetase syndrome who were diagnosed with antibodies specific for myositis associated with different clinical findings. All patients responded to immunosuppressive therapy, and rituximab was the most used.
CONCLUSIONS: It is necessary to search for specific autoantibodies related to the syndrome in suspected clinical cases and in other rheumatological diseases refractory to the usual treatment.

Keywords: Amino Acyl-tRNA Synthetases, Autoantibodies, myositis

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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