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Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma

Hussein A. Abbas, Behrang Amini, Wei-Lien Wang, Vinod Ravi

(Division of Cancer Medicine, Hematology-Oncology Fellowship Program, University of Texas MD Anderson Cancer Center, Houston, TX, USA)

Am J Case Rep 2020; 21:e918878

DOI: 10.12659/AJCR.918878


BACKGROUND: Primary cardiac tumors are rare and mostly benign. Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months. The diagnosis of cardiac sarcomas may be challenging. Treatment entails surgical resection despite the high rate of recurrence, as well as adjuvant chemotherapy.
CASE REPORT: In this report, we discuss a case of a 58-year-old male with undifferentiated pleomorphic primary cardiac sarcomas who received multiple lines of treatment that included surgery, chemotherapy, and targeted therapy and was alive more than 4 years after his diagnosis. Herein, we discuss the different treatment regimens utilized and we present detailed imaging of his case findings at different treatment stages.
CONCLUSIONS: Treatment of undifferentiated pleomorphic cardiac sarcoma requires a multidisciplinary approach. Surgery and adjuvant treatment are commonly utilized, while neoadjuvant treatment is under investigation.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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