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Alessandra Surace, Viola Liberale, Marta D’Alonzo, Silvia Pecchio, Maria Grazia Baù, Nicoletta Biglia
(Department of Obstetrics and Gynecology, AOU City of Health and Science, University of Turin, Turin, Italy)
Am J Case Rep 2020; 21:e919856
Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast lesion.
CASE REPORT: PASH is reported in a young female in treatment for neurological diseases with multi-drug therapy (clonazepam, valproate and risperidone). Her menstrual cycles are irregular, and she reached menarche very late.
CONCLUSIONS: The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in 24% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate, risperidone and progesterone could increase the level of progesterone that could stimulate PASH growth.