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07 February 2020 : Case report  USA

A Case of Evans Syndrome with Acute Hemolysis and Hemoglobin Cast Nephropathy

Challenging differential diagnosis, Rare disease

Felicia Sadie Couri1EF*, Manasa Kandula1EF

DOI: 10.12659/AJCR.920760

Am J Case Rep 2020; 21:e920760

Abstract

BACKGROUND: Evans syndrome is characterized by ‘warm’ autoimmune hemolytic anemia and autoimmune thrombocytopenia, and is more common in the pediatric population than in adults. Evans syndrome is often associated with underlying autoimmune disease, connective tissue disease, immune deficiency disorders, lymphoproliferative disorders, or malignancy of the immune system. A case is presented of acute kidney injury due to hemoglobin cast nephropathy in an adult man with Evans syndrome.

CASE REPORT: A 60-year-old man was diagnosed with Evans syndrome, which was complicated by acute renal failure that required treatment with hemodialysis. Laboratory tests and renal histology confirmed a diagnosis of hemolysis-associated hemoglobin cast nephropathy.

CONCLUSIONS: The diagnosis of Evans syndrome is important as it may be associated with underlying hematological and immunological disorders. Although rare, hemoglobin cast nephropathy due to hemolysis can be a cause of acute kidney injury in patients with Evans syndrome.

Keywords: Acute Kidney Injury, Anemia, Hemolytic, Anemia, Hemolytic, Autoimmune, Purpura, Thrombocytopenic, Idiopathic, Thrombocytopenia, Antineoplastic Agents, Immunological, Glucocorticoids, Hemolysis, Prednisone, rituximab

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923