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Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion

Hala A. Helmi, Waleed Alsarhani, Hind Manaa Alkatan, Ammar C. Al-Rikabi, Yasser H. Al-Faky

(College of Medicine, Alfaisal University, Riyadh, Saudi Arabia)

Am J Case Rep 2020; 21:e925134

DOI: 10.12659/AJCR.925134

BACKGROUND: Sebaceous gland carcinoma (SGC) is a rare malignant lesion that occurs on the eyelids. It is known to mimic other benign or malignant lesions in clinical presentation, such as a chalazion, basal cell carcinoma, and squamous cell carcinoma. The histopathological diagnosis is the mainstay for diagnosis and is often challenging.
CASE REPORT: We describe a case of SGC in a 53-year-old woman who presented with a cauliflower-appearing lesion with pearly telangiectatic vessels and raised margins at the lower eyelid margin. Clinically, we suspected a diagnosis of basal cell carcinoma. Upon complete resection of the lesion, the final diagnosis was SGC based on the histopathological features and immunohistochemical staining characteristics of the tissue.
CONCLUSIONS: Due to the possibility of SGC presenting similarly to other lesions, it is essential for ophthalmologists to have a high index of suspicion in its diagnosis. The early and accurate diagnosis of such lesions is important for appropriate management to prevent metastasis or recurrence related to advanced tumors.

Keywords: Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Immunohistochemistry, Pathology, Sebaceous Gland Neoplasms

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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