02 July 2004
Differential effects of norepinephrine on brain and other less vital organs detected by a multisite multiparametric monitoring system
Ari Kraut, Efrat Barbiro-Michaely, Avraham MayevskyMed Sci Monit 2004; 10(7): BR215-220 :: ID: 11699
Abstract
Background:Under emergency situations, the protection of the most vital organs in the body, the brain and the heart, may result in a decrease in tissue perfusion, mitochondrial dysfunction and energetic failure, in “less-vital” organs (skin, G-I tract, kidney etc.). One of these pathways includes the secretion of epinephrine and norepinephrine. The aim of the present study was to test the effect of norepinephrine injection on the vitality of four different organs (vital and “less-vital”) monitored simultaneously.Material/Methods:The four organs monitored were, the brain- a vital organ and three “less vital” organs-the kidney, liver and testis. The vitality of the organs was evaluated by monitoring the levels of microcirculatory tissue blood flow (TBF) and the level of mitochondrial NADH measured from the surface of each organ. The hemodynamic state, TBF, was monitored by the laser Doppler flowmetry (LDF) and the metabolic state was evaluated by surface fluorometry-reflectometry.Results:The results indicated that following norepinephrine bolus injection the increase in mean arterial pressure (MAP) was associated with an increase in cerebral blood flow and a decrease in all three “less vital” organs TBF. As a result, NADH levels in the brain remained stable whereas in all other organs NADH increased due to the hypoperfusion developed and the lack of enough oxygen in these organs.Conclusions:The significant correlation between the hemodynamic state of the organs and its mitochondrial redox state may serve as an indicator of tissue vitality under “Brain Sparing” conditions.
Keywords: Blood Pressure - drug effects, Blood Pressure - physiology, Brain - blood supply, Brain - drug effects, Cerebrovascular Circulation - drug effects, Cerebrovascular Circulation - physiology, Hemodynamic Processes - drug effects, Hemodynamic Processes - physiology, Kidney - blood supply, Kidney - drug effects, Laser-Doppler Flowmetry, Liver - blood supply, Liver - drug effects, Microcirculation - drug effects, Microcirculation - physiology, Mitochondria - metabolism, NAD - metabolism, Norepinephrine - pharmacology, Rats, Wistar, Renal Circulation - drug effects, Renal Circulation - physiology, Spectrometry, Fluorescence - methods, Testis - blood supply, Testis - drug effects, Blood Pressure - physiology, Brain - drug effects, Cerebrovascular Circulation - physiology, Hemodynamics - physiology, Kidney - drug effects, Laser-Doppler Flowmetry, Liver - drug effects, Microcirculation - physiology, Mitochondria - metabolism, NAD - metabolism, Norepinephrine - pharmacology, Rats, Wistar, Renal Circulation - physiology, Spectrometry, Fluorescence - methods, Testis - drug effects
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952