01 July 1999
Effect of treatment with methylprednisolone upon concentration of soluble form of IL-2R alpha and soluble forms of adhesive molecules : ICAM-1 and VCAM-1 in serum of patients with multiple sclerosis
Małgorzata Bilińska, Irena Frydecka, Ryszard PodemskiMed Sci Monit 1999; 5(4): CR692-696 :: ID: 503491
Abstract
The bout of multiple sclerosis implies activation of autoreactive mononuclear cells of peripheral blood and increased expression of adhesive cells on cerebral vessel endothelium. This results in the migration of cells and consequently, in the formation of perivascular infiltrations consisting of lymphocytes and macrophages, as well as the destruction of myelin in the brain and spinal cord. Steroid-therapy reduces clinical symptoms of MS bout, while nuclear magnetic resonance reveals the decrease of demyelinization foci after treatment. The aim of the present work was to evaluate the effect of methylprednisolone therapy upon the activation of immune system and clinical status estimated on EDSS scale. In our study, concentrations of sIL-2R alpha, sICAM-1 and sVCAM-1 were investigated in blood serum with the use of ELISA immunoenzyme assay. The study was performed in the group of 15 patients with the first bout of multiple sclerosis, who received intravenous infusion of methylprednisolone (1g) daily for 5 consecutive days. Neurological examinations as well as the determination of serum levels of cellular differentiation antigens listed above were performed before the start of therapy and 4 weeks after its completion. Control group was formed of 20 healthy persons. In patients with the first bout of the disease, mean serum concentrations of sIL-2R, sICAM-1 and sVCAM-1 were significantly higher when compared with the results obtained in control group. 4 weeks after therapy with methylprednisolone, a considerable improvement of neurological status was observed in patients from the study group. At that time, return to normal serum levels of mean sVCAM-1 concentration and a considerable decrease of mean sICAM-1 concentration were observed, while mean level of sIL-2R alpha did not change in a significant way. The improvement on EDDS scale after treatment correlated with the decrease of sICAM-1 in blood serum. The results of our study suggest that a beneficial clinical effect of steroid therapy in patients with multiple sclerosis may partly result from its inhibiting influence on the expression of adhesive cells, which consequently may lead to reduced migration of activated cells of immune system to central nervous system.
Keywords: Immune System, steroid therapy, Multiple Sclerosis
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952